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Dana Köln Video

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It is mandatory to procure user consent prior to running these cookies on your website. Dana Köln About The Author admin. This website uses cookies to improve your experience.

We'll assume you're ok with this, but you can opt-out if you wish. It is caused by mutations in the LIG4 gene that decrease but do not eliminate gene expression.

Mice with a Lig4 gene mutation that dramatically reduces LigIV activity Lig4YC mice have recently been identified and shown to recapitulate the immunodeficiency and growth retardation seen in human patients with LigIV syndrome.

Richard Cornall and colleagues, at Oxford University, United Kingdom, have now characterized in these mice defects in the development, function, survival, and proliferation of immune cells known as lymphocytes that may well bring about the immunodeficiency observed in individuals with LigIV syndrome.

They also observed an abnormally high incidence of cancers arising in the thymus, the organ where T cells develop, leading them to suggest that these tumors and the T cell leukemias reported in some patients with LigIV syndrome may arise through similar mechanisms.

Kenji Kadomatsu and his colleagues, at Nagoya University Graduate School of Medicine, Japan, have now identified a new regulator of the mouse renin-angiotensin system: the protein midkine.

Using this approach it was determined that midkine regulates the activity of ACE, a known controller of blood pressure that is the target of many drugs that lower blood pressure.

The authors conclude from these results that midkine is an important regulator of the renin-angiotensin system. Louis, have used a newly developed high throughput digital technology NanoString nCounter to show that biomarkers of disease can be measured using very small amounts of clinical material.

In the study, traditional microarray approaches were used to identify a gene expression signature that is specific to a subtype M3 of acute myeloid leukemia.

The new high throughput technology was then used to validate the M3-specific gene signature because of the small size of the patient samples.

Nearly all of the genes tested demonstrated highly significant statistical agreement with the microarray data and were enriched in a mouse model of the condition.

The authors therefore conclude that the NanoString nCounter Analysis System is a useful tool to quantify the mRNA abundance of a large number of genes from an expression signature using very small amounts of clinical material and that this method will provide a valuable diagnositic tool.

Louis, Missouri, USA. A new study has discovered that the brains of people suffering from tone-deafness are in fact lacking in white matter.

The study published in the current issue of Brain was conducted by a team of researchers from the Universite de Montreal, the Montreal Neurological Institute and the Newcastle University Medical School.

Tone deafness or congenital amusia is a lifelong disability that prevents otherwise normal-functioning individuals from developing basic musical skills.

The study examined the structural neural correlates of tone deafness. Magnetic resonance imaging data from a group of tone deaf people were compared with the images of people with normal musical ability to find out what area of the brain was responsible for this condition and what possible anatomical anomaly could correlate with this "music disorder.

Isabelle Peretz of the Universite de Montreal. Krista L. The results have implications for the understanding of normal acquisition of musical abilities and for the diagnosis and remediation of this music-specific disorder.

It is an inter-university research and training facility that has made Montreal the global centre for the study of the musical brain.

Co-directed by Dr. Isabelle Peretz and Dr. Robert Zatorre from the MNI, the Laboratory brings together researchers who share an interest in understanding the cerebral substrates of auditory cognition and, in particular, the processing of music by humans.

A complete list of the study's authors and their affiliations: Krista L. Hyde 1,2 , Robert J. Zatorre 2 ,Timothy D. Griffiths 4 ,Jason P.

It brings together 2, professors and researchers, accommodates more than 55, students, offers some programs at all academic levels, and awards about 3, masters and doctorate diplomas each year.

About the Montreal Neurological Institute The Montreal Neurological Institute is a McGill University research and teaching institute, dedicated to the study of the nervous system and neurological diseases.

Founded in by the renowned Dr. Wilder Penfield, the MNI is one of the world's largest institutes of its kind.

MNI researchers are world leaders in cellular and molecular neuroscience, brain imaging, cognitive neuroscience and the study and treatment of epilepsy, multiple sclerosis and neuromuscular disorders.

The MNI, with its clinical partner, the Montreal Neurological Hospital MNH , part of the McGill University Health Centre, continues to integrate research, patient care and training, and is recognized as one of the premier neuroscience centres in the world.

A group of researchers in Australia and Taiwan has developed a new way to analyze the health of human teeth using lasers.

As described in the latest issue of Optics Express, the Optical Society's OSA open-access journal, by measuring how the surface of a tooth responds to laser-generated ultrasound, they can evaluate the mineral content of tooth enamel -- the semi-translucent outer layer of a tooth that protects the underlying dentin.

This is the first time anyone has been able to non-destructively measure the elasticity of human teeth, creating a method that can be used to assess oral health and predict emerging dental problems, such as tooth decay and cavities.

Wang and his advisor Simon Fleming, a physics professor at the University of Sydney's Institute of Photonics and Optical Science, collaborated on the study with dental researchers at the University of Sydney and ultrasonic evaluation researchers at National Cheng Kung University in Tainan City, Taiwan.

Stronger than bone, enamel is the hardest and the most mineralized substance of the human body -- one of the reasons why human teeth can survive for centuries after a person has died.

It envelops teeth in a protective layer that shields the underlying dentin from decay. Throughout a person's lifetime, enamel constantly undergoes a cycle of mineral loss and restoration, in which healthy teeth maintain a high mineral content.

If the balance between mineral loss and gain is lost, however, teeth can develop areas of softened enamel -- known as carious lesions -- which are precursors to cavities and permanently damaged teeth.

Enamel demineralization is caused by bad oral hygiene. Not brushing, for instance, can lead to the build-up of dental plaques, and bacteria in these plaques will absorb sugars and other carbohydrates a person chews and produce acids that will dissolve the minerals in tooth enamel.

Quantifying the mineral content of tooth enamel can help dentists determine the location and the severity of developing dental lesions. Existing methods for evaluating enamel are limited, however.

Dentists can visually assess the teeth, but dental lesions can be hard to spot in certain parts of the mouth because they are obscured by dental plaque, saliva, or the structure of a tooth itself.

Dentists can use sharp instruments to probe the enamel, but this can be destructive to the teeth and gums. X-ray scans can reveal dental lesions, but they give no information on the level of mineralization.

For research purposes, "nano-indentation" is commonly used for gaining information on the elasticity of tooth enamel -- a measure of its mineral content -- but nano-indentation destroys the measured regions of the enamel in the process and is only used to look at extracted teeth.

What Wang, Fleming, and their colleagues wanted to do was to develop a clinical method that would give as much information as nano-indentation and could be used to assess tooth enamel in actual patients while being completely non-destructive.

So they developed a way to measure the elasticity of tooth enamel by adapting laser ultrasonic surface wave velocity dispersion, a method similar to what industrial engineers use to evaluate the integrity of thin films and metals.

The method uses short duration laser pulses to excite ultrasonic waves that propagate along the surface and penetrate only a small distance into a tooth.

The velocity of these waves is influenced by the elastic properties of the enamel on a tooth, and by detecting the ultrasonic waves with fiber optics at various points, they can determine the enamel's elasticity, which is directly related to its mineralization.

In their Optics Express article, Wang, Fleming, and their colleagues showed that they could use this technique on extracted human teeth.

They have not yet tested the technique on a living person's teeth, and it will likely take several years before any eventual device is ready for use in the dentist's office.

Molecular Detection Inc. Cassie Pope, Clinical Scientist of St. The proprietary technology in the Detect-Ready kits provides a unique differential diagnosis engine that produces highly accurate results, minimizing the false positives and false negatives experienced with other MRSA screening kits.

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